BRUNCKO, MILAN,DING, HONG,ELMORE, STEVEN,KUNZER, AARON R.,LYNCH, CHRISTOPHER L.,MCCLELLAN, WILLIAM,PARK, CHEOL-MIN,PETROS, ANDREW,SONG, XIAOHONG,WANG, XILU,TU, NOAH,WENDT, MICHAEL D.
申请号：
ES10178948
公开号：
ES2461615T3
申请日:
2004.11.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A pharmaceutical combination comprising a therapeutically acceptable amount of (a) a compound having the formula (I) ** Formula ** or a therapeutically acceptable salt thereof, wherein A1 is C (A2)； A2 is H, F, CN, C (O) OH, C (O) NH2 or C (O) OCH3； B1 is R1, OR1, NHR1, N (R1) 2 or NR1C (O) N (R1) 2； D1 is H, F, Cl or CF3； E1 is H, F or Cl； Y1 is H, CN, NO2, F, Cl, CF3, OCF3, NH2, C (O) NH2, or B1 and Y1, together with the atoms to which they are attached, are imidazole or triazole； R1 is phenyl, pyrrolyl, cyclopentyl, cyclohexyl, piperidinyl, tetrahydrofuranoyl, tetrahydropyranyl, tetrahydrothiopyranyl or R5； R5 is C1 alkyl, C2 alkyl, C3 alkyl, C4 alkyl, C5 alkyl or C6 alkyl, each of which is unsubstituted or substituted with one or two or three substituents C4 spiroalkyl, C5 spiroalkyl, R7, OR7, SR7, SO2R7 , NHR1, N (R7) 2, C (O) R7, C (O) NH2, C (O) NHR7, NHC (O) R7, NHSO2Rc, NHC (O) OR7, NHC (O) NH2, NHC (O ) CH (CH3) NHC (O) CH (CH3) NH2, OH, C (O) OH or NH2 independently selected； R7 is phenyl, furanyl, imidazolyl, pyridinyl, tetrazolyl, thiazolyl, thienyl, 1,3-benzoxazolyl, 1,3-benzodioxolyl, 1,3-benzothiazole, cyclopropyl, cyclobutyl, cyclohexyl, azetidinyl, morpholinyl, piperazinyl, piperidinyl, thiomorphyl, thiomorphyl thiomorpholinyl sulfone-7-azabicyclo [2.2.1] heptanyl, 8-azabicyclo [3.2.1] octanyl, 4,5-dihydro-1H25 imidazolyl 2-oxa-5-azabicyclo [2.2.1] heptanyl, 1,4,5, 6-tetrahydropyrimidinyl or R11； R11 is C1 alkyl, C2 alkyl, C3 alkyl or C4 alkyl, each of which is unsubstituted or substituted with one or two or three substituents R12, OR12, N (R12) 2, C (O) N (R12) 2 , OH, C (O) OH, NH2, CF3, F, Cl, Br or I independently selected； R12 is 1,3-benzodioxolyl, pyridinyl, morpholinyl or C1 alkyl； Z1 is phenyl or pyridinyl, each of which is substituted with cyclohexenyl, piperazinyl, piperidinyl, 1,2,3,6-tetrahydropyridinyl or octahydropyrrolo [3,4-c] pyrrolyl, each of which is substituted with CH2R37, C (spiroalkyl C2) (R37) or C (O) R37； R37 is phenyl, na
