Mach, Robert,Hawkins, William,Spitzer, Dirk,Vangveravong, Suwanna,Van Tine, Brian
申请号：
NZ72481915
公开号：
NZ724819A
申请日:
2015.04.01
申请国别(地区):
NZ
年份:
2020
代理人:
摘要：
Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds of formula (III) comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC50 value below 5 μΜ against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo, and led to 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.
