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激酶抑制劑
专利权人:
NISSAN CHEMICAL CORPORATION
发明人:
NISHINO, TAITO,西野泰斗,OTSUKA, KEIICHIRO,大敬一朗,FUKAZAWA, NATSUKI,深泽菜月,深澤菜月,NAKAJIMA, HIROYUKI,中嶋宏之,AIHARA, AYAKO,相原彩子
申请号:
TW108119738
公开号:
TW202005643A
申请日:
2019.06.06
申请国别(地区):
TW
年份:
2020
代理人:
摘要:
A purpose of the present invention is to provide a novel kinase inhibitor and the likes, and to provide a treating agent of diseases using the above inhibitor and a screening method for drug discovery and the likes. The following compound represented by formula (I) or salt thereof comprises LATS (especially LATS2) which is a key kinase of Hippo signal transduction pathway, and can inhibit multiple kinase or can treat diseases or tissue lesions accompanying with cell proliferation deficiency. Therefore, the present invention is useful in the study field of cell functions or disease related with such as Hippo signal transduction pathway. Further, the present invention is useful in the therapeutical field for treating the related diseases.(In formula, all symbols are same as those defined in the present specification.)本發明之目的為提供新穎的激酶抑制劑等,以及提供應用該種抑制劑等之疾患之治療劑或藥物開發的篩選方法等。下述式(I)所示之化合物或其鹽包含屬於Hippo訊息傳遞路徑的主要激酶之LATS(特定而言,LATS2),可抑制複數種激酶,此外,可治療伴隨細胞增殖不全之疾患或組織損傷。從而,本發明在例如與Hippo訊息傳遞路徑相關之細胞機能或疾病等之研究領域中實屬有益。再者,在治療該種疾病等之醫療領域中實屬有益。{式中,各記號係如說明書中所定義。}
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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