A jinggangmycin and ipconazole fungicidal composition, a weight ratio of jinggangmycin to ipconazole being (1-68):(40-1). The fungicidal composition of the present invention has a remarkable synergistic effect in preventing and controlling fusarium head blight of wheat and barley, powdery mildew of wheat and barley, rust of wheat and barley, sheath blight of wheat and barley, leaf blight of wheat and barley, rice blast, rice false smut and rice sheath blight, particularly the synergistic effect in preventing and controlling fusarium head blight of wheat and barley is more remarkable, and the contamination level of DON toxin in grains can be significantly decreased.