СОАРЕС ДА СИЛЬВА Патрисио Мануэль Виэйра Араужо (PT),БОНИФАСИО Мария Жуан Маседо да Сильва (PT)
申请号：
RU2015120164
公开号：
RU2015120164A
申请日:
2013.11.14
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group； R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl； X signifies CH2, oxygen atom or sulphur atom； n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2； and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof.
