Various aspects of a system and a method to provide assistance in a surgery in presence of tissue deformation are disclosed herein. In accordance with an embodiment, the system includes an electronic device that receives one or more tissue material properties of a plurality of surface structures of an anatomical portion. One or more boundary conditions associated with the anatomical portion may also be received. Surface displacement of the anatomical portion may be determined by matching a first surface of the anatomical portion before deformation with a corresponding second surface of the anatomical portion after the deformation. The volume displacement field of the anatomical portion may be computed based on the determined surface displacement, the received one or more tissue material properties, and the received one or more boundary conditions.
