The present invention provides impedance data having an impoved spatial resolution, both with regard to depth and lateral extension, which enables a detection of diseased skin conditions, such a malignant melanoma, at an early stage. Specifcally, the present invention is implemented in a probe, medical devices and medical systems including such a probe, and methods using such a probe for measuring electrical impedance of tissue of a subject. A switching circuit is arranged for selectively activate electrode pairs of the probe in accordance with a predetermined activation scheme, the predetermined activation scheme including to activate adjacent electrodes in a successive manner, to gradually scan tissue of the subject at a first tissue depth so as to obtain a sequence of impedance signals from the tissue depth.本發明提供具有與深度延伸及橫向延伸相關之一改良式空間解析度的阻抗資料,該阻抗資料能偵測早期患病皮膚之狀況,如惡性黑素瘤。具體言之,以一探針、包含此一探針的醫療器件與醫療系統及使用用於量測一受試者之組織之電阻抗的此一探針之方法來實施本發明。一開關電路係配置用於根據一預定啟動方案選擇性啟動該探針之電極對,該預定啟動方案包含以一連續方式啟動相鄰電極以逐步掃描一第一組織深度處之該受試者之組織,以便獲得來自該組織深度的一序列阻抗信號。20...量測器件21...探針22...電極部分23A...電極棒23B...電極棒23C...電極棒23D...電極棒23E...電極棒24...識別晶片25...開關電路26...啟動按鈕27...主單元28...阻抗量測電路29...控制器件30...系統環境32...診斷單元34...處理單元