LAURENT, Alain,ROSE, Yannick,MORRIS, Stephen,JAQUITH, James
申请号：
ES12767447
公开号：
ES2590144T3
申请日:
2012.04.03
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of the formula 1: ** Formula ** wherein m is an integer from 0 to 1； n is an integer from 0 to 2； R1 is selected from alkyl, heteroalkyl, carbocyclyl and heterocyclyl； R1 is also selected from aryl or heteroaryl, wherein aryl and heteroaryl can be further substituted by the groups selected from: 1) Halogen, 2) Alkoxy, 3) Amino, 4) -N (H) C (O) O- alkyl 5) -N (H) SO2-aryl, 6) -N (H) SO2-heteroaryl, 7) -N (H) CON (H) -aryl, 8) and -N (H) CON (H) - heteroaryl； R2a, R2b, R2c, R2d, R2e, R2f are independently selected from hydrogen, alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl. R2a and R2b, R2c and R2d or R2e and R2f can be fused to form a 3- to 8-membered cycloalkyl or heterocyclyl ring system； X is selected from CH2, O, S (O) n, NR3； R3 is selected from hydrogen, alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, -C (O) R4, -C (O) OR4, -S (O) 2R4, -C (O) NR4R5, -S (O ) 2NR4R5, -C (S) NR4R5； R4 and R5 are independently selected from alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl or R4 and R5 can be fused to form a 3- to 8-membered heterocyclyl ring system； wherein alkyl represents C1-6 alkyl； alkenyl represents C2-6 alkenyl； alkynyl represents C2-6 alkynyl； Aryl includes 5, 6, and 7-membered, substituted or unsubstituted single ring aromatic groups in which each 30 atom of the ring is carbon or polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjacent rings where at least one of the rings is aromatic carbocyclyl includes a substituted or unsubstituted non-aromatic ring in which each ring atom is carbon or polycyclic ring systems having two or more cyclic rings in those with two or more carbons are common to two adjacent rings where at least one of the rings is carbocyclic； heteroaryl includes ring structures of 5 to 7 substituted or unsubstituted aromatic members, whose ring structures include one to four heteroatoms or polycyclic ring systems having two or
