One aspect of the present invention relates to substituted pyridines and pharmaceutiallyacceptable salts thereof that are active against a range of mammalian maladies.Another aspect of the invention relates to a pharmaceutical composition, comprisinga compound of the present invention or a pharmaceutically acceptable salt thereof；and a pharmaceutically acceptable excipient. The present invention also relatesto methods of treating a range of mammalian maladies or conditions, includingbut not limited to hyperlipidemia, hypercholesterolemia, atherosclerosis,coronary artery disease, congestive heart failure, cardiovascular disease,hypertension, coronary heart disease, angina, pellagra, Hartnup's syndrome,carcinoid syndrome, arterial occlusive disease, obesity, hypothyroidism,vasoconstriction, osteoarthritis, rheumatoid arthritis, diabetes, Alzheimer'sdisease, lipodystrophy, or dyslipidemia, raising serum high-density lipoprotein(HDL) levels, and lowering serum low-density lipoprotein (LDL) levels.
