Being the dermal remedy system in order to prescribe the active ingredient through the skin,a) Lining formation, andb) b1) The active ingredient and, at least the gel formation medicine of 1 genera and, the 1st formation which at least includes with the plastic medicine of 1 genera and the 1st polyisobutylene Andb2) The active ingredient and, at least the gel formation medicine of 1 genera and, the two-layer which at least includes with the plastic medicine of 1 genera and the 2nd polyisobutylene is included,Implication the reservoir which is provided with respect to the said lining formation,The 1st polyisobutylene, the 2nd polyisobutylene is something of the type which differs,At least, 1st formation, includes the active ingredient of not yet dissolution with configuration of the active ingredient grain,The said active ingredient, huentaniru or is that similar chemical compoundThe dermal remedy system which is featured.皮膚を通して有効成分を投与するための経皮治療システムであって、a)裏打ち層、ならびにb)b1)有効成分と、少なくとも1種のゲル形成剤と、少なくとも1種の可塑剤と、第1ポリイソブチレンとを含む第1層;およびb2)有効成分と、少なくとも1種のゲル形成剤と、少なくとも1種の可塑剤と、第2ポリイソブチレンとを含む第2層を含む、該裏打ち層上に設けられたリザーバーを含み、第1ポリイソブチレンが、第2ポリイソブチレンとは異なる種類のものであり、少なくとも第1層が、未溶解の有効成分を有効成分粒子の形態で含んでおり、該有効成分が、フェンタニルまたはその類似化合物であることを特徴とする経皮治療システム。