MICRO-ORGANISME POUR ADMINISTRER UN MÉDICAMENT POUR LE TRAITEMENT D'UNE MALADIE GASTRO-INTESTINALE, QUI EXPRIME ET SÉCRÈTE LA PROTÉINE P8, ET COMPOSITION PHARMACEUTIQUE COMPRENANT CE MICRO-ORGANISME DESTINÉE À LA PRÉVENTION OU AU TRAITEMENT D'UNE MALADIE GASTRO-INTESTINALE
The present invention relates to a microorganism for drug delivery, which has been transformed with a gene construct comprising a therapeutically active peptide, which can be delivered safely into the intestines through oral administration, and which can express and secrete the therapeutic peptide in the gastrointestinal tract, and also relates to a pharmaceutical composition for prevention or treatment of gastrointestinal disease, which includes the same. The present invention is directed to a lactic acid bacteria drug delivery system capable of overexpressing and secreting a lactic acid bacteria-derived anticancer protein, which is developed by introducing the anticancer protein into a lactic acid bacteria expression and secretion system. It is expected that the lactic acid bacteria drug delivery system will be widely used as a natural protein therapeutic agent against gastrointestinal disease in the medical field.
