A tissue removal system for extracting a tissue specimen from a patient and a related method are disclosed. The system has a flexible container with an opening associated with a proximal end, and a distal end. The system also has a plurality of wires removably coupled to an interior of the flexible container in a pre-collection configuration wherein the plurality of wires form a receiving space for receiving the tissue specimen and wherein the plurality of wires are positioned in a pattern. The pattern is selected to divide the tissue specimen into at least four pieces in response to at least one pulling force on the plurality of wires.
