A staple cartridge that includes a multi-staple driver is disclosed. The multi-staple driver is configured to drive multiple staples from the staple cartridge. The staples are arranged in a staple array in which at least one staple is angularly-oriented relative to the longitudinal axis of the staple cartridge. The multi-staple driver can drive staples at various angular orientations and/or from multiple rows of staple cavities. A driverless staple cartridge is also disclosed. A sled in the driverless cartridge is configured to directly engage and drive staples. The staples are arranged in a staple array in which at least one staple is angularly-oriented relative to the longitudinal axis of the driverless staple cartridge.
