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HYALURONIC ACID COMPOSITION
专利权人:
КУ-МЕД АБ (SE)
发明人:
ЭДСМАН Катарина (SE),ВИЕБЕНШЕ Оса (SE)
申请号:
RU2013140182/15
公开号:
RU2013140182A
申请日:
2012.02.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The use of an ascorbic acid derivative selected from the group consisting of ascorbyl phosphates, ascorbyl sulfates and ascorbyl glycosides in an injection composition of hyaluronic acid, further comprising: - hyaluronic acid and a therapeutically appropriate concentration of local anesthetic selected from the group consisting of local amide and complex anesthetics types or combinations thereof, to prevent or reduce the effects of local anesthetic on the viscosity and / or elastic modulus G 'of the composition due to thermal sterilization, where the concentration of the specified ascorbic acid derivative in the composition is in the range from 0.01 to 5 mg / ml. 2. The use according to claim 1, wherein the hyaluronic acid composition does not exhibit increased stability compared to the same composition without an ascorbic acid derivative. The use according to any one of the preceding claims, wherein said local anesthetic is lidocaine, and its concentration is preferably in the range of 1 to 5 mg / ml. The use according to claim 1, wherein said ascorbic acid derivative is selected from the group consisting of ascorbyl phosphates and ascorbyl glycosides or a combination thereof, preferably ascorbyl glycoside, more preferably ascorbyl glucoside. The use according to claim 1, wherein the concentration of said ascorbic acid derivative is in the range from 0.01 to 0.5 mg / ml. The use of claim 4, wherein said ascorbic acid derivative is selected from the group consisting of sodium ascorbyl phosphate (SAP) or magnesium ascorbyl phosphate (MAP), and a concentration of said sodium ascorbyl phosphate (SAP)1. Применение производного аскорбиновой кислоты, выбранного из группы, состоящей из аскорбилфосфатов, аскорбилсульфатов и аскорбилгликозидов, в инъекционной композиции гиалуроновой кислоты, дополнительно включающей:- гиалуроновую кислоту и- терапевтически соответствующую концентрацию местного анестетика, выбранного из группы, состоящей из местных анестетиков амидного и сл
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