The present invention relates to a transdermal therapeutic system for administering the active ingredient buprenorphine, with at least one carboxylic acid which determines the solubility of the buprenorphine in the matrix layer and is likewise absorbable, for pain therapy, with significantly increased active ingredient utilization.本發明係關於一種用於投與活性成分布普雷諾芬(buprenorphine)之經皮治療系統,具有至少一種決定布普雷諾芬在基質層內之溶解度且同樣可吸收的羧酸;該系統係用於疼痛療法,具有明顯增加的活性成分利用性。