JOSEPH, JAMES DAVID,HAGER, JEFFREY H.,SENSINTAFFAR, JOHN LEE,LU, NHIN,QIAN, JING,SMITH, NICHOLAS D.
申请号：
PE0000952015
公开号：
PE06442015A1
申请日:
2013.07.26
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The Invention relates to polypeptides of androgen receptor modified that are resistant to inhibition by an inhibitor of androgen receptor. The Invention describes compositions and Kits that contain combinations of androgen receptor modified polypeptides and Methods of use of the modified polypeptides of the androgen receptor.In addition, The Invention describes Methods of using the modified polypeptides of androgen receptor as agents of Analysis for the identification and Design of androgen receptor modulators of Third Generation.The Invention also described androgen receptor modulators of third generation that inhibit the activity of the androgen receptor modified polypeptides.Pharmaceutical compositions are also described, and Drugs that include the compounds described in the invention, as well as Methods of using such androgen receptor modulators, alone and in combination with other Compounds, for the treatment of diseases or conditions Is, including cancers, such as Prostate cancers resistant to CASTRATIONThey are Mid or dependent on androgen receptorLa invencion describe polipeptidos del receptor de androgeno modificado que son resistentes a la inhibicion por un inhibidor del receptor de androgeno. En la invencion se describen composiciones, combinaciones y estuches que contienen los polipeptidos del receptor de androgeno modificados y metodos de uso de los polipeptidos del receptor de androgeno modificados. En la invencion se describen, ademas, metodos de uso de los polipeptidos del receptor de androgeno modificados como agentes de analisis para la identificacion y el diseno de moduladores del receptor de androgeno de tercera generacion. En la invencion se describen, ademas, moduladores del receptor de androgeno de tercera generacion que inhiben la actividad de los polipeptidos del receptor de androgeno modificados. Se describen, ademas, composiciones farmaceuticas y medicamentos que incluyen los compuestos que se describen en la invencion, asi como tambien me
