The present invention relates to impregnated alumina nanoparticies for detoxification of chemical contaminants. It also relates to the development of compositions having alumina nanoparticies and reactive chemicals loaded/impregnated over it to give it a permanent self decontaminating feature. This material can be used with gas phase chemical agents removal/decontamination devices and filtration systems with suitable modifications (converting impregnated nanoparticies to granules by mechanical compression technique) to remove and detoxify chemical agents effectively in less time.