The Invention provides compounds which have the General formula I, which are inhibitors of i.e., Autotaxin (ATX), where R1 is cycloalkyl substituted phenyl among others. R2 is replaced, among others and is co - (OR), among others is n or CH W or -, - S -, among Others m, N, P, and q is 1 or 2.Preferred compounds: (3aR, 6aS) - 5 - (5 - hidroxipicolinoil) hexahidropirrolo [3,4-c] pyrrole carboxylate - 2 (1H) - 3.5 - diclorobencilo Trans 2 - (4 - hexahidro sulfamoilbenzoil) - 1H pyrrolo [3,4-c] pyridine carboxylate (6H) - 5 - 3.5 - diclorobencilo.La invencion proporciona compuestos que tienen la formula general I, que son inhibidores de autotaxina (ATX), donde: R1 es cicloalquilo sustituido, entre otros. R2 es fenilo sustituido, entre otros Y es -OC(O)-, entre otros A es -N- o CH- W es -O-, -S-, entre otros m, n, p y q es 1 o 2. Compuestos preferidos: (3aR,6aS)-5-(5-hidroxipicolinoil)hexahidropirrolo[3,4-c]pirrol-2(1H)-carboxilato de 3,5-diclorobencilo trans-2-(4-sulfamoilbenzoil)hexahidro-1H-pirrolo[3,4-c]piridina-5(6H)-carboxilato de 3,5-diclorobencilo.
