Methods and compositions for the treatment of proliferative and pathogenic diseases

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专利权人:

プレジデント アンド フェローズ オブ ハーバード カレッジ

发明人:

チン，シュエビン,フー，ウェイグオ,チン,シュエビン,フー,ウェイグオ

申请号：

JP2012525663

公开号：

JP5925678B2

申请日:

2010.08.18

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The invention features proteins including an antibody, or functional derivatives thereof, that bind hCD59 and have the activity of domain 4 of the Streptococcus intermedins intermedilysin (ILY) protein. In order to prevent the independent induction of CDC and ADCC, the antibodies of the invention can bind the same hCD59 epitope as ILYd4 and/or contain modifications that disrupt the interaction between the antibody and complement.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/