MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION

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专利权人:

GERON CORPORATION

发明人:

GRYAZNOV, SERGEI,PONGRACZ, KRISZTINA

申请号：

CA2536015

公开号：

CA2536015C

申请日:

2004.09.09

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

Compounds comprising an oligonucleotide moiety covalently linked to a lipidmoiety are disclosed. The oligonucleotide moiety comprises a sequence that iscomplementary to the RNA component of human telomerase. The compounds inhibittelomerase activity in cells with a high potency and have superior cellularuptake characteristics.

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