Mehlen, Patrick,Delloye-Bourgeois, Celine,Bernet, Agnes,Delcros, Jean Guy,Nony, Pascale
申请号：
AU2011231579
公开号：
AU2011231579A1
申请日:
2011.03.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention is relative to the use of an effective amount of an agonist of the CDO's apoptotic function for the preparation of a drug to induce cell apoptosis in a patient having tumoral cells bearing CDO and expressing SHH. The agonist may be a CDO fragment, a fusion protein comprising a CDO fragment, an antibody against SHH, or a siRNA which is capable of inhibiting SHH expression. The invention also concerns a pharmaceutical composition containing an agonist of the CDO's apoptotic function or a CDO polypeptide or an antibody specific to CDO, and an agonist of the PTC1's apoptotic function or a PTC1 polypeptide or an antibody specific to PTC1, and a pharmaceutically acceptable excipient or vehicle.
