The present invention is directed to lyophilized pharmaceutical preparations comprising melphalan flufenamide, or pharmaceutically acceptable salts thereof, and sucrose. Further independent claims are directed to methods for their preparation, compositions comprising the lyophilized pharmaceutical preparations and their use in the treatment of cancer.La presente invención se refiere a preparaciones farmacéuticas liofilizadas que comprenden el melfalán flufenamida o sales farmacéuticamente aceptables del mismo, métodos para su preparación, composiciones que comprenden las preparaciones farmacéuticas liofilizadas y su uso en el tratamiento del cáncer.