Imaging catheter assemblies as well as related methods of manufacturing and imaging are disclosed. The imaging catheter assembly can include an interior lumen containing an intravascular imaging device as well as an acoustic fluid medium comprising ethanol. Such an imaging catheter assembly can be contained within a package, such that when the imaging catheter assembly is removed from the package it can begin generating image data without needing to perform one or more preparation steps on the imaging catheter assembly. Related methods of manufacturing include applying a vacuum to an interior lumen of an imaging catheter assembly and filling the interior lumen with an acoustic fluid medium comprising ethanol. After filling the interior lumen, the imaging catheter assembly is packaged within a packaging container for later use.
