PROBLEM TO BE SOLVED: To provide an orally disintegrable tablet containing duloxetine hydrochloride that can be taken more comfortably due to a reduced rough taste in the oral cavity and has improved acid resistance.SOLUTION: An orally disintegrable tablet contains a granule composed of: (a) a nuclear particle composed of mannitol with a particle size of more than 150 μm and less than 250 μm, (b) a main agent layer obtained by coating the nuclear particle with duloxetine hydrochloride, (c) a separation layer coating the main agent layer, and (d) an enteric-coated layer obtained by coating the separation layer with an enteric-coated polymer.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】口腔内でのざらつきを低減するため、服用感が向上し、かつ、耐酸性に優れたデュロキセチン塩酸塩を含む口腔内崩壊錠を提供すること。【解決手段】(a)粒子径が150μmより大きく250μm未満であるマンニトールからなる核粒子と、(b)前記核粒子にデュロキセチン塩酸塩を被覆した主薬層と、(c)前記主薬層を被覆した分離層と、(d)前記分離層に腸溶性高分子を被覆した腸溶層と、からなる顆粒を含む口腔内崩壊錠を提供する。【選択図】なし
