The disclosure includes compositions and methods for the production of an immune response against porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV. The disclosure is based in part on the use of two or more peptide domains, each with a different sequence, from the PRRSV GP5 protein ectodomain. Compositions and methods comprising polypeptides containing the two or more domains, or nucleic acids encoding them, are described.本揭示包括一種用來對抗豬繁殖與呼吸道症候群(PRRS)病毒(或PRRSV)以產生免疫反應之組成物及方法。本揭示某種程度上以使用二或更多個來自PRRSV GP5蛋白質細胞膜外區之胜肽區段為基礎，其中每個含有不同序列。本揭示描述出一種包含二或更多個區段之多胜肽或編碼出其的核酸之組成物及方法。
