Devices, systems, and methods for visually depicting a vessel and evaluating treatment options are disclosed. In some instances, a method of evaluating a vessel of a patient includes moving a second instrument longitudinally through a vessel of the patient from a first position to a second position while maintaining a first instrument in a fixed longitudinal position with respect to the vessel； obtaining pressure measurements from the first and second instruments while the second instrument is moved longitudinally through the vessel； visually depicting the vessel on a display based on the obtained pressure measurements； and modifying the visual depiction of the vessel to simulate one or more treatment options. Systems for performing such methods are also provided.
