A method for supporting a user, a corresponding computer program product, a corresponding data medium, and a corresponding imaging system are provided. According to the method, a three-dimensional (3D) data set depicting a target object is provided, and at least one two-dimensional (2D) image of the target object is automatically acquired. The 2D image and the 3D data set are automatically registered with each other by a 2D/3D registration. A spatial direction in which the 2D/3D registration exhibits greatest uncertainty is automatically specified. A signal for aligning an instrument that is provided for the purpose of examining the target object is then automatically generated and output as a function of the specified spatial direction in order to support the user.
