KRAH DAVID L.,DEHAVEN JILL,KRISS JENNIFER A.,BARR COLLEEN M.,YAGODICH MARY
申请号：
NZ60654911
公开号：
NZ606549A
申请日:
2011.08.04
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Discloses an inactivated varicella zoster virus (VZV), and compositions and vaccines comprising said inactivated VZV, wherein the infectivity of the VZV is undetectable and wherein the inactivated VZV induces an immune response against VZV when administered to a patient. In embodiments of the compositions described herein, the VZV is inactivated with gamma radiation. Also disclosed is a method of preparing an inactivated VZV vaccine, the method comprising gamma irradiating a sample comprising a VZV using from about 5 kGy to about 50 kGy of gamma radiation. Also disclosed is a method of treatment of or immunization against HZ or other disease associated with the reactivation of VZV, the method comprising administering to a subject a vaccine or pharmaceutical composition comprising a therapeutically effective amount of an inactivated VZV and a pharmaceutically acceptable carrier, wherein the VZV is inactivated by gamma irradiation.
