methods for preparing a conditionally active biological protein, and a conditionally active biological response modifier, conditionally active biological protein, and pharmaceutical composition
GREGORY FROST,GERHARD FREY,HWAI WEN CHANG,JAY M. SHORT
申请号：
BRPI1008971
公开号：
BRPI1008971A2
申请日:
2010.03.09
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
A method of generating conditionally active biologic antibodies from parent antibodies, in particular therapeutic antibodies, which are more active at an aberrant physiological condition than at a normal physiological condition and which may reversibly or irreversibly inactivated at the wild type normal physiological condition. For example, evolved antibodies are may be less active or inactive at normal body temperature or pH, than at other aberrant body temperatures or at an aberrant pH.
