Therapeutic compositions and/or formulations are provided comprising: at least one cross linked protein matrix wherein the at least one cross linked protein matrix comprises at least one protein residue and at least one saccharide containing residue and methods of producing the same. The cross linked protein matrix may be derived from cross linking a full length or substantially full length protein such as tropoelastin elastin albumin collagen collagen monomers immunoglobulins insulin and/or derivatives or combinations thereof with a saccharide containing cross linking agent such as a polysaccharide cross linking agent derived from for example hyaluronic acid or a cellulose derivative. The therapeutic compositions may be administered topically or by injection. The present disclosure also provides methods systems and/or kits for the preparation and/or formulation of the compositions disclosed herein.
