A cooling system for inducing diving reflex and central nervous system protective hypothermia has a cooler, a refrigerant dispenser, a cooling assembly, a controller and an infusing unit. The refrigerant dispenser connects the cooler. The cooling assembly connects the refrigerant dispenser and communicates with the cooler and has a head cooling set. The controller coordinates the refrigerant dispenser and the infusing unit according to the detection of the physical signal including naso-pharyngeal temperature, and cerebral oximetry signal. The infusing unit connects to the controller and has a catheter. When in use, the cooled liquid is pumped into (1) head cooling set covering the face of the patient to induce diving reflex, (2) the infusing unit having an esophago-gastric tube to lower the temperature inside the stomach. Therefore, an effective, precise diving reflex and central nervous system protective hypothermia can be achieved by this invention.
