PROBLEM TO BE SOLVED: To provide a sustained-release formulation which can minimize the pH dependence of an elution rate in an insoluble drug sustained-release formulation.SOLUTION: A sustained-release formulation can release an insoluble drug independently of pH, where the formulation contains the insoluble drug and a polyvalent cation while they are dispersed in a matrix.COPYRIGHT: (C)2014,JPO&INPIT【課題】難溶性薬物徐放性製剤における溶出速度のpH依存性を極小化できる徐放性製剤を提供すること。【解決手段】難溶性薬物と多価カチオンがマトリクス中に分散した状態で含有されている、該難溶性薬物をpH非依存的に放出できる徐放性製剤。【選択図】なし
