JOSEPH MARIA GERARDUS BARBARA CALS,SANDER BERNARDUS NABUURS
申请号：
BR112017026223
公开号：
BR112017026223A2
申请日:
2016.06.03
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
ror gamma modulators (rory). The present invention relates to novel compounds according to formula I (formula I) or a pharmaceutically acceptable salt thereof wherein - a11? a14 are n or cr11, cr12, cr13, cr14, respectively, provided that no more than two of the four positions a can be simultaneously n； R1 is c (2-6) alkyl, c (3-6) cycloalkyl, c (3-6) cycloalkyl (1-3) alkyl, (di) c (3-6) cycloalkylamino or (di) (c (3 - 6) cycloalkyl (1-3) alkyl) amino； R5 is h, hydroxyethyl, methoxyethyl, c (1-6) alkyl, c (6-10) aryl, c (6-10) aryl and c (1-3) alkyl, c (1-9) heteroaryl, c ( 1-9) heteroaryl (1-3) alkyl, c (3-6) cycloalkyl, c (3-6) cycloalkyl (1-3) alkyl, c (2-5) heterocycloalkyl or c (2-5) heterocycloalkyl- c (1-3) alkyl； - the sulfonyl group with r1 is represented by one of r7, r8 or r9； - R15 is h, c (1-6) alkyl, c (36) cycloalkyl, c (36) cycloalkyl (13) alkyl, c (6-10) aryl, c (610) aryl (1-3) ) alkyl, c (19) heteroaryl, c (19) heteroaryl (13) alkyl, c (25) heterocycloalkyl or c (25) heterocycloalkyl (13) alkyl； - and r16 is c (1-6) alkyl, c (36) cycloalkyl, c (36) cycloalkyl (13) alkyl, c (6-10) aryl, c (610) aryl (1-3) alkyl, c (19) heteroaryl, c (19) heteroaryl (13) alkyl, c (25) heterocycloalkyl or c (25) heterocycloalkyl (13) alkyl. The compounds may be used as rory inhibitors and are useful for the treatment of rory mediated diseases.moduladores de ror gama (rory). a presente invenção está relacionada a novos compostos de acordo com a fórmula i (fórmula i) ou seu sal aceitável farmaceuticamente em que - a11 ? a14 são n ou cr11, cr12, cr13, cr14, respectivamente, com a condição de que não mais de duas das quatro posições a possam ser simultaneamente n； - r1é c (2-6) alquil, c (3-6) cicloalquil, c (3-6) cicloalquilc (1-3) alquil, (di)c(3-6)cicloalquilamino ou (di)(c(3- 6)cicloalquil c(1-3)alquil) amino； - r5 é h, hidróxietil, metóxietil, c (1-6) alquil, c (6-10) aril, c (6-10) aril c (1-3) alquil, c (1-9) heteroaril, c (1-9 ) heteroarilc (1-3) alquil, c (3-6)
