AN, Kyungjun,HAM, Dongsoo,KIM, Hun,KIM, Sunghyun,SHIN, Jinhwan,HOPFER, Robert,KENSINGER, Richard,KYAW, Moe,TALAGA, Philippe
申请号：
SG11202006387Q
公开号：
SG11202006387QA
申请日:
2019.02.04
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 21 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid (TT) or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11 A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, where the capsular polysaccharides of serotypes two of serotypes 1, 3, and 5 are conjugated to TT and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.
