A Histotripsy therapy transducer is provided that can include any number of features. In some embodiments, the transducer is sized and configured to direct Histotripsy energy through the perineal window into the prostate. The Histotripsy therapy transducer can include a notch or opening near the periphery of the transducer to accommodate a transrectal imaging probe. The notch or opening in the therapy transducer allows for movement of the therapy with respect to the imaging probe without contact or interference from the imaging probe. In some embodiments, the transducer can be "heart-shaped" or round. Methods of use are also described.
