In one aspect, the invention provides therapeutic agent nanoparticles coated with cholesteryl esters, formulations of the nanoparticles suitable for injection, methods for administering therapeutic agents and for treating diseases and conditions treatable by the therapeutic agents using the formulations. In a related aspect, the invention provides synthetic high density lipoprotein nanoparticles useful for therapeutic agent delivery, and methods for their preparation and use.於一個態樣中，本發明提供以膽固醇酯塗覆的治療劑奈米粒子、適於注射的奈米粒子調配物，用於投藥治療劑以及用於治療疾病及病況的方法，該疾病及病況係使用該調配物之該治療劑可治療者。於一相關的態樣中，本發明提供有用於治療劑遞輸之合成性高密度脂蛋白奈米粒子，以及其等之製備方法及用途。
