BELVIN, MARCIA,CHAN, IRIS T.,FRIEDMAN, LORI,HOEFLICH, KLAUS P.,PRESCOTT, JOHN,WALLIN, JEFFREY
申请号：
PE0004702012
公开号：
PE18162012A1
申请日:
2010.10.11
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to a method of treating a patient who has a locally advanced or metastatic solid tumor which comprises administering a combined formulation containing (a) an inhibitor of phosphatidylinositol 3-kinase (PI3K) such as 4 - (2 - (1H - indazol - 4-yl) - 6 - ((4 - (piperazin - 1 - (methylsulfonyl) L) methyl) thieno [3,2 - d] pyrimidin-4-yl) morpholine (GDC - 0.941) or (S) - 1 - (4 - ((2 - (5 - aminopirimidin - il) - 7 - methyl - 4 - morfolinotieno [3,2-d] pyrimidine 6 - yl) methyl) - 1 - piperazin il) - 2 - hidroxipropan - 1 - One in an amount of 80 mg to 180 mg and (b) an inhibitor of mitogen activated protein kinase (MEK) as [3Difluor - 4 - 2 - (4 - Fluorine Iodine - (phenylamino) - phenyl] - (S) - 3 - hydroxy - 3 - piperidin-2-yl - azetidin - 1 - il) methanone (GDC - 0973 - 518 \/ XL) in an amount of 20 mg to 60 mgSE REFIERE A UN METODO DE TRATAMIENTO DE UN PACIENTE QUE TIENE UN TUMOR SOLIDO LOCALMENTE AVANZADO O METASTASICO QUE COMPRENDE ADMINISTRAR UNA FORMULACION COMBINADA QUE CONTIENE A) UN INHIBIDOR DE FOSFATIDILINOSITOL-3-QUINASA (PI3K) TAL COMO 4-(2-(1H-INDAZOL-4-IL)-6-((4-(METILSULFONIL)PIPERAZIN-1-IL)METIL)TIENO[3,2-d]PIRIMIDIN-4-IL)MORFOLINA (GDC-0941) O (S)-1-(4-((2-(2-AMINOPIRIMIDIN-5-IL)-7-METIL-4-MORFOLINOTIENO[3,2-d]PIRIMIDIN-6-IL)METIL)PIPERAZIN-1-IL)-2-HIDROXIPROPAN-1-ONA EN UNA CANTIDAD DE 80MG A 180MG Y B) UN INHIBIDOR DE PROTEINA QUINASA ACTIVADA CON MITOGENO (MEK) TAL COMO [3,4-DIFLUOR-2-(2-FLUOR-4-YODO-FENILAMINO)-FENIL]-((S)-3-HIDROXI-3-PIPERIDIN-2-IL-AZETIDIN-1-IL)-METANONA (GDC-0973/ XL-518) EN UNA CANTIDAD DE 20MG A 60MG
