PROCEDE PERMETTANT D'ATTENUER LES EFFETS SECONDAIRES D'UN TRAITEMENT A L'ACIDE RETINOIQUE ET/OU D'AMELIORER SON EFFICACITE SANS ENTRAVER L'EFFICACITE D'UN TEL TRAITEMENT
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION;ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人:
JACOBSON, ELAINE L.,JACOBSON, MYRON K.,COYLE, RUSSELL,KIM, HYUNTAE,COYLE, DONNA L.
申请号：
CA2679315
公开号：
CA2679315C
申请日:
2008.02.27
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to the use of nicotinic acid alkyl esters, especially myristyl nicotinate, to inhibit side effects associated with retinoic acid therapy. Also a part of the invention is a method for improving skin cell differentiation by administering the nicotinic acid alkyl ester in an amount sufficient to increase expression of caspase 14 and filaggrin. Deficiencies in expression of these molecules can be treated in this way as well.
