UNIFORM, RIGID, SPHERICAL NANOPOROUS CALCIUM PHOSPHATE PARTICLES THAT DEFINE AN INTERNAL SPACE AND AN AMOUNT OF ACTIVE AGENT PRESENT IN THE INTERNAL SPACE ARE PROVIDED. ALSO PROVIDED ARE TOPICAL DELIVERY COMPOSITIONS THAT INCLUDE THE ACTIVE AGENT LOADED PARTICLES, AS WELL AS METHODS OF MAKING THE PARTICLES AND TOPICAL COMPOSITIONS. THE PARTICLES AND COMPOSITIONS THEREOF FIND USE IN A VARIETY OF DIFFERENT APPLICATIONS, INCLUDING ACTIVE AGENT DELIVERY APPLICATIONS. (FIGURE 5)