BRUNCKO, MILAN,DING, HONG,DOHERTY, GEORGE,ELMORE, STEVEN,HASVOLD, LISA,HEXAMER, LAURA,KUNZER, AARON R.,SONG, XIAHONG,SOUERS, ANDREW J.,SULLIVAN, GERHARD M.,TAO, ZHI-FU,WANG, GARY T.,WANG, XILU,WENDT,
申请号：
PE0022182012
公开号：
PE10442013A1
申请日:
2010.11.22
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to a compound of formula (i), where A1 is n or C (A2) A2 is H, F, CL, NO2, CF3, among others B1 is H, F, CL, BR, o, NO2, among others D1 is H, CN, NO2, N3, among others E1 is H, CN, NO2, no, Oh, among others y1 is H, CN, NO2, C (o) o, F, CL, among others G1 is H or C (o) or R26, R27 is Z1 and Z 2 is R28, R29, R30 Z1A panel rc-z2a and are ch2ch2 or CH2, z12a z12a is alquileno C2 - C6 L1 is C (n) so2nh, NH,Among others, R26 is phenylene, among others it is heteroarileno R27, R28 is among others phenylene, among others it is heteroarileno R29, R30 is cicloalquileno, among others cicloalquenileno, among others.Compounds are Favorites: 4 - (4 - (4 - Chloro - [1,1 - biphenyl - 2 - yl) methyl] piperazin-1-yl) - N - [3 - [4 - (nitro - tetrahydro - 2H - piran - 4 - methyl) amino] phenyl] sulfonyl) - 2 - (1h pyrrolo [2,3-b] pyridin - 5 - iloxi) benzamide, 4 - (4 - (4 - Chloro - [1,1 - biphenyl - 2 - yl) methyl] piperazin-1-yl} {- N - (4 - [(3 - (4 - ilpropil) amino] - 3 - nitrofe Nil) sulfonyl) - 2 - (1h pyrrolo [2,3-b] pyridin - 5 - iloxi) benzamide, among others.It also relates to a Pharmaceutical composition. These compounds inhibit the activity of the anti apoptotic Proteins bcl-2 and are useful in the treatment of Cancer and Immune DiseasesREFERIDA A UN COMPUESTO DE FORMULA (I), DONDE A1 ES N O C(A2) A2 ES H, F, Cl, NO2, CF3, ENTRE OTROS B1 ES H, F, Cl, Br, OH, NO2, ENTRE OTROS D1 ES H, CN, NO2, N3, ENTRE OTROS E1 ES H, CN, NO2, N3, OH, ENTRE OTROS Y1 ES H, CN, NO2, C(O)OH, F, Cl, ENTRE OTROS G1 ES H O C(O)O Z1 ES R26 O R27 Z2 ES R28, R29 O R30 Z1A Y Z2A SON CH2, CH2CH2 O Z12A Z12A ES ALQUILENO C2-C6 L1 ES C(N)NH, SO2NH, ENTRE OTROS R26 ES FENILENO, ENTRE OTROS R27 ES HETEROARILENO, ENTRE OTROS R28 ES FENILENO, ENTRE OTROS R29 ES HETEROARILENO, ENTRE OTROS R30 ES CICLOALQUILENO, CICLOALQUENILENO, ENTRE OTROS. SON COMPUESTOS FAVORITOS: 4-{4-[(4-CLORO-1,1-BIFENIL-2-IL)METIL]PIPERAZIN-1-IL}-N-({3-NITRO-4-[(TETRAHIDRO-2H-PIRAN-4-ILMETIL)AMINO]FENIL}SULFONIL)-2-(1H-PIR
