The invention relates to vaccines for the treatment and prophylaxis of staphylococcal infection and can be used for a specific immunotherapy. The vaccine comprises: Staphylococcus aureus – 15 strains, Staphylococcus haemolyticus – 3 strains, Staphylococcus epidermidis – 3 strains. In accordance with the manufacturing method, an agar-grown bacterial culture is washed off the surface of a solid growth medium with pyrogen-free distilled water and placed into sterile containers； to remove growth medium impurities, the bacterial strains are washed with distilled water and subjected to centrifugation, following which the supernatant is discarded； the resulting pellet consisting of the biomass of the individually grown bacteriological strain culture is suspended in pyrogen-free distilled water for injection and standardised, wherein microorganism strains are taken in equal quantities； the standardised strain suspension is inactivated by autoclaving； equal quantities of a preparation of an embryonic origin or saline or water for injection are added to the containers with the inactivated bacteria. The vaccine is administered subcutaneously in the area of the inferior angle of the scapula, alternately in the right and left sides, the dose being increased at each subsequent injection. The invention makes it possible to increase the immunogenic effect of the vaccine and to enhance the immunological and clinical effects following vaccination while avoiding allergic reactions, and to reduce time required for producing the vaccine.L'invention concerne des vaccins pour traiter et prévenir des infections par staphylocoques et peut être utilisée pour une immunothérapie spécifique. Le vaccin comprend: un staphylocoque doré: 15 souches； un staphylocoque hémolythique: 3 souches； et un staphylocoque épidermique: 3 souches. L'invention concerne un procédé de préparation dans lequel une culture de bactéries sur agar-agar est rincée depuis la surface d'un milieu de culture solide avec de l'
