БЕККЕР, Герман Петрович;BEKKER, German Petrovich; German Petrovich;BEKKER
发明人:
NIKONOV, Boris Alekseevich,НИКОНОВ, Борис Алексеевич
申请号：
RURU2017/000624
公开号：
WO2018/124933A1
申请日:
2017.08.29
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
The invention relates to pharmacology and concerns a composition for preparing an anti-tumour agent that is a complex of bivalent platinum salts and alloferon peptide, and to pharmaceutical compositions containing said complexes. The invention may be used to produce preparations used in oncology. The technical result of the invention is the possibility of using the composition as the basis for different types of preparations for injection or for a lyophilisate, which have both anti-tumour effectiveness and reduced toxicity. Said technical result is achieved by the fact that a composition is claimed for the preparation of an anti-tumour agent in the form of a solution for injection or a lyophilisate containing alloferon, characterised in that a complex compound of bivalent platinum with an alloferon oligopeptide is used as the active component. A method of preparing an anti-tumour agent on the basis of the above-described composition is characterised in that alloferon is gradually introduced into a solution of cis-platin in 0.9% sodium chloride, and then the solution is mixed for 15 minutes, after which it is sterilised by filtration through a filter having 0.2-mcm pores, then poured into ampoules and sealed. A preparation can be produced in the form of a lyophilisate with mannitol as the filler.L'invention se rapporte au domaine de la pharmacologie et concerne une composition pour préparer un agent antitumoral qui consiste en un complexe de sels de platine bivalent et de peptide d'alloférone, ainsi qu'une composition pharmaceutique contenant lesdits complexes. L'invention peut être utilisée dans la production de préparations utilisées en oncologie. Le résultat technique consiste en la possibilité, grâce à cette composition, de produire différents types de préparations pour injection ou d'un lyophilisat, qui ont à la fois une efficacité antitumorale et une toxicité réduite. Ce résultat technique est obtenu grâce à cette composition pour préparer un agent antitumoral,
