The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (22 wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a. solvate thereof Cr a prodrug thereof is useful as a drug component having Trk- inhibiting activity in prophylaxis and/or therapy at diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.
