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Inhibidores del receptor H4 para tratar el tinnitus
- 专利权人:
- Sensorion
- 发明人:
- WERSINGER, Eric
- 申请号：
- ES13727899
- 公开号：
- ES2683380T3
- 申请日:
- 2013.06.10
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- An inhibitor of the Histamine Receptor Type 4 (H4R) for use in the treatment of tinnitusIn the H4R inhibitor is selected from: - [(1 - 5 - Chloro - 1H indole - 3 - il) carbonyl] - 4 - metilpiperazina, - 4 - ((3R) - 3 - 5 - 1 - il aminopirrolidin) - 6.7 - dihydro - 5h benzo [6,7] cyclohepta - [1.2 - d] pyrimidine 2 - ilamina - cis-4 - (piperazin-1-yl) - 5,6,7a, 8,9,10,11,11a - octahidrobenzofuro [2,3] quinazolin - H - 2 - Amine - 7 - (furan-2 - yl) - 4 - (piperazin-1-yl) - 2 - quinazolin Amine,- 1 - (4 - (2 - amino - 4 - (4 - metilpiperazin - 1 - il) pyrimidin-4-yl) - 3,4 - dihidroisoquinolin - 2 (1H) - yl) - 2 - [1 - (ciclopentiletanona, - 5 - Chloro - 1h-benzimidazol-2 - il) carbonyl] - 4 - metilpiperazina maleate,- N4 - (ciclopropilmetil) - 6 - [(3R) - 3 - (methylamino) pyrrolidin-1-yl] - pyrimidine - 2.4 - diamine, N4 - (ciclopropilmetil) - 6 - [(3R) - 3 - (methylamino) pyrrolidin-1-yl] pyrimidine - 2.4 - diamine tartrate,- (R) - 4 - (3 - amino - pyrrolidin-1-yl) - 6 - 2 - isopropyl - pyrimidine ilamina, - 2 - isobutyl - 6 - (3 - (methylamino) azetidin IL - 1 - 4 - pyrimidin-2-yl) - Amine - 2 - isobutyl - 6 - ((3R) - 3 - (methylamino) pyrrolidin-1-yl) pyrimidin-2-yl) - amine- 2 - cyclohexylmethyl - 6 - ((3R) - 3 - (methylamino) pyrrolidin-1-yl) Amine pyrimidine - 4, - 2 - (4-fluorobenzyl) - 6 - (3 - (methylamino) azetidin IL - 1 - 4 - pyrimidin-2-yl) - amine- 2 - 6 - cyclopropyl - (3 - (methylamino) azetidin IL - 1 - 4 - pyrimidin-2-yl) - Amine - 2 - Tert Butyl - 4 - (3 - (methylamino) azetidin IL - 1 - pyrimidin-2-yl) - 4 - isopropyl Amine, - 2 - 6 - (3 - (methylamino azetidin IL - 1) - pyrimidin-2-yl) - 4 - amine- 2 - (ciclopropilmetil) - 6 - (3 - (methylamino) azetidin IL - 1 - pyrimidin-2-yl) - Amine - 4, 6 - (3 - (methylamino) azetidin - 1 - il) - 2 - (phenoxymethyl) pyrimidin-2-yl) - amine- 2 - 2-cyclopropyl-1 - 6 - ((3R) - 3 - (methylamino) pyrrolidin-1-yl) Amine pyrimidine - 4, - 2 - Tert Butyl - 6 - ((3R) - 3 - (methylamino) pyrrolidin-1-yl) pyrimidin-2-
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
