A composition for the use in topical antimicrobial or anti-infective treatment of skin and soft tissue infections is described, the composition includes an antiseptic substance and a photosensitizer at the time of application, wherein the antiseptic substance exerts an antimicrobial or anti-infective effect on microorganisms or their biofilm on skin, soft tissue and wounds and the photosensitizer catalyzes a photodynamic antimicrobial or anti-infective effect upon irradiation with light of appropriate wavelength, power-density and energy-dose, directed at the microorganisms or their biofilm on skin, soft tissue and wounds, for simultaneous application of both the antiseptic substance and the photosensitizer.
