As for this invention, a) phosphatidyl choline b) anionic characteristic phosphatide c) according to need, 1 weight % the cholesterol below the entire lipid quantity And d) according to need, the remedy medicine It includes, the average grain size which was measured by dynamic light scattering is under 100nm here, lipid based dispersed ones are offered. In addition as for this invention, the pharmacy composition which includes this kind of dispersed ones is offered, the process which prescribes the effective quantity of this kind of dispersed ones in the same way is included, and it offers also the method of making the curative effect cause in the animal. In addition as for this invention, for example solubility of the remedy medicine is made to increase with in vivo (, when there are no lipid based dispersed ones of this invention, when the remedy medicine is prescribed biologically by comparison with the available quantity, the remedy medicine it increases the available quantity biologically) to offer method, this method includes the process which prescribes the medicine which is combined with lipid based dispersed ones of this invention.本発明は、a)ホスファチジルコリン;b)アニオン性リン脂質;c)必要に応じて、総脂質量の1重量%以下のコレステロール;およびd)必要に応じて、治療剤;を含み、ここで動的光散乱によって測定された平均粒子サイズが100nm未満である、脂質ベースの分散物を提供する。本発明はまた、このような分散物を含む薬学的組成物を提供し、同様にこのような分散物の有効量を投与する工程を包含する、動物において治療効果を生じさせる方法もまた提供する。本発明はまた、インビボで治療剤の溶解度を増大させる(例えば、本発明の脂質ベースの分散物がないときに治療剤が投与される場合の生物学的に利用可能な量と比較して、治療剤の生物学的に利用可能な量を増加させる)方法を提供し、この方法は、本発明の脂質ベースの分散物と組み合わせた薬剤を投与する工程を包含する。
