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Method for preparing high-purity benidipine hydrochloride
专利权人:
ヘフェイ ベイニ メディカル テクノロジー カンパニー リミテッド
发明人:
チャン、チャオヤン
申请号:
JP2014505487
公开号:
JP5878975B2
申请日:
2011.09.28
申请国别(地区):
JP
年份:
2016
代理人:
摘要:
Disclosed is a method for preparing benidipine hydrochloride, which comprising: 1) during the pre-treatment stage including acylchloridizing the main ring of dihydropyridine and then linking the side chain to synthesize directly benidipine hydrochloride, ultrasound technology is introduced, and the reactant material is dispersed and dissolved by untrasound to increase reaction rate; and/or 2) during the post-treatment stage, ultrasound technology is introduced and crude crystals or product obtained by heating to dryness of benidipine hydrochloride obtained via the method described above or any other synthetic routes is dissolved once more and then highly purified benidipine hydrochloride is obtained by untrasound.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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