The present invention introduces novel invasive intermittent negative pressure ventilation for treatment of adults ventilator dependent respiratory failure (VDRF) in various advanced neuromuscular disorders (NMDs). It's a combination of invasive intermittent negative pressure ventilator (IINPV) and continues positive airway pressure (CPAP) into transportable ventilator. Implementation of invasive negative pressure ventilation is via chest tubes to each pleural space, and CPAP is applied via nasal mask or nasal prongs. The IINPV's initiation of breath is patient-triggered via a flow sensor incorporated in CPAP nasal mask/nasal prongs. This novel concept of VDRF management in advanced NMDs will prove to be superior over present modalities of treatment in many aspects which include but not limited to avoidance of tracheostomies, reduction of recurrent respiratory infection, greater patient's independence and quality of life, preserved ability to speak and clear airways spontaneously, liberation from positive pressure mechanical ventilation etc.
