The present invention relates to exosomes with an increased amount of growth factors, which are obtained from stem cells cultured in a medium containing an epithelial growth factor (EGF) and/or a fibroblast growth factor (FGF). It is expected that the nano-sized exosomes isolated from a stem cell culture liquid can penetrate into the dermal layer of the skin and thereby increase their regenerative effect. In addition, since exosomes contain a large amount of various growth factors, they provide effects such as skin regeneration and anti-aging, promotion of collagen synthesis, hair growth, restoration of shrunken hair follicles, and wound healing through proliferation and activation of fibroblasts, which are skin component cells.
