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Proteins with high immunoreactivity and method for their production
专利权人:
Ivan Benes
发明人:
Ivan Benes,Silke Thomsen-Bosslet
申请号:
US12883620
公开号:
US09005574B2
申请日:
2010.09.16
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention relates to (glyco-) proteins, in particular monoclonal antibodies, which have an immunoreactivity of >81%, preferably >90%. The inventive monoclonal antibodies are produced using a fluidized bed reactor in conjunction with a conventional protein-chemical purification method or preferably with a purification method involving less column chromatography. The monoclonal antibodies thus produced are suitable, in gamma-irradiated form, e.g. Tc-99m labeled, for the in vivo diagnosis of inflammatory diseases and bone marrow metastases. In alpha- or beta-irradiated form, e.g. astatine or Re-188 or Y-90 labeled form, the inventive monoclonal antibodies can be used, for example, in the treatment of leukemia.
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